P1.06-035 Frequency and Clinical Relevance of EGFR-Mutations and EML4-ALK-Translocations in Octagenarians with NSCLC
نویسندگان
چکیده
منابع مشابه
Frequency and clinical relevance of EGFR mutations and EML4–ALK translocations in octogenarians with non-small cell lung cancer
Background Tyrosine kinase inhibitors (TKIs) have improved response rates in some patients with non-small cell lung cancer (NSCLC), and testing for EGFR mutation and ALK translocation is recommended for all patients with advanced lung adenocarcinoma. The frequency of driver mutations in elderly and very elderly patients has not been described. Patients and methods We reviewed EGFR and ALK in ...
متن کاملClinical outcomes of thoracic radiotherapy for locally advanced NSCLC with EGFR mutations or EML4-ALK rearrangement.
BACKGROUND Little is known about the occurrence and consequences of epidermal growth factor receptor gene (EGFR) mutations and the fusion of the echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) genes in locally advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS We retrospectively examined 37 patients with locally advanced NSCLC treate...
متن کاملClinical and epidemiological study of EGFR mutations and EML4-ALK fusion genes among Indian patients with adenocarcinoma of the lung
BACKGROUND Mutation in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) is a common feature observed in lung adenocarcinoma. A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the intracellular domain of anaplastic lymphoma kinase (ALK), named EML4-ALK, has been identified in a subset of non-small-cell lung cancer (NSCLC) tumors. The objective...
متن کاملPre-Treatment Serum CEA and EGFR Mutations and EML4-ALK Fusion Gene in Lung Adenocarcinoma
Lung cancer is the most common cause of cancerrelated deaths, where it is associated with a 5-year worldwide survival rate of less than 15% (Jemal et al., 2011). Among new diagnoses of pulmonary carcinoma, Non-small-cell lung cancer (NSCLC) accounts for approximately 80% (Ozgul et al., 2013). Despite great efforts to improve the survival of patients with NSCLC, the outcomes are still considered...
متن کامل: metadiscourse in introduction sections of applied linguistics and physics research articles: exploring variation in frequency and type
abstract in written mode of language, metadiscourse markers are used commonly to help writers in general and academic writers in particular to produce coherent and professional texts. the purpose of the present study was to compare introduction sections of applied linguistics and physics articles regarding their use of interactive and interactional metadiscourse markers based on the model pro...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2016.11.899